ChemicalBook > CAS DataBase List > N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide

N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide

Product Name
N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide
CAS No.
918505-61-0
Chemical Name
N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide
Synonyms
CS-1029;PLX 4032;INXN-1001;ZELBORAF.(R).;BRAF inhibitor;PLX-4032(RG7204);Vemurafenib-Analog;Raf kinases,inhibit,Inhibitor,BRAF inhibitor,Raf;N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin...;N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-2-propanesulfonamide
CBNumber
CB82489948
Molecular Formula
C22H18F2N4O3S
Formula Weight
456.47
MOL File
918505-61-0.mol
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N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide Property

Density 
1.45
storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (109.54 mM; Need ultrasonic)
form 
Powder
pka
6.54±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FV15248
Product name
PLX 4032
Packaging
50mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FV15248
Product name
PLX 4032
Packaging
100mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-0055
Product name
BRAFinhibitor
Purity
98.61%
Packaging
10mg
Price
$180
Updated
2021/12/16
Biosynth Carbosynth
Product number
FV15248
Product name
PLX 4032
Packaging
250mg
Price
$187.5
Updated
2021/12/16
ApexBio Technology
Product number
A3263
Product name
BRAFinhibitor
Packaging
10mg
Price
$293
Updated
2021/12/16
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N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide Chemical Properties,Usage,Production

Uses

Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. Potent B-Raf inhibitor

N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide Suppliers

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View Lastest Price from N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide manufacturers

Career Henan Chemical Co
Product
N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide 918505-61-0
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

918505-61-0, N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamideRelated Search:


  • PLX-4032(RG7204)
  • N-(2,4-Difluoro-3-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-2-sulfinamide
  • PLX 4032
  • BRAF inhibitor
  • ZELBORAF.(R).
  • 2-PropanesulfonaMide, N-[2,4-difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-
  • N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide
  • N-(2,4-Difluoro-3-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]-pyridine-3-carbonyl)phenyl)propane-2-sulfin
  • N-(2,4-Difluoro-3-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]-pyridine-3-carbonyl)phenyl)propane-2-sul
  • N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-2-propanesulfonamide
  • CS-1029
  • Vemurafenib-Analog
  • N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin...
  • INXN-1001
  • Raf kinases,inhibit,Inhibitor,BRAF inhibitor,Raf
  • 918505-61-0
  • C22H18F2N4O3S